Machine Clinical Trials Professor Neil Piller
Clinical trials.
Professor Neil Piller - Flinders University Clinical Trials using the
Sun Ancon Chi Machine - Published articles regarding the clinical trial results:

Professor Neil Piller - Lymphologist and Team Leader Lymphoedema Assessment Clinic:
Prof. Piller works at the Flinders University Medical Center in South Australia and specializes in clinical and experimental research on primary and secondary lymphoedemas and oedemas, their assessment, treatment and management. He belongs to the Australasian Lymphology Association and the Lymphoedema Association of Australia and is the Patron of the Lymphoedema Support Group of South Australia.

Prof Piller.Chi Machine
Prof. Piller conducted the clinical trials for the Sun Ancon Chi Machine.

"Professor Piller along with Dr Stephen Birrell established the Lymphoedema Assessment Clinic in 1993. The Clinic specializes in the assessment and differential diagnosis of lymphoedemas, oedemas and lipoedemas. The Clinic uses a range of assessment tools such as perometry, bio-impedance and tonometry to objectively determine tissue changes and as the basis of the diagnosis. The Clinic reviews patients from across Australia and overseas and as an outcome presents patients with a comprehensive treatment and management plan." - Flinders University Medical Center.

Flinders University.
Prestigious Flinders University, Adelaide, South Australia.

Flinders Medical Devices and Technologies (FMDAT) - Member Neil Piller.
Research, Develop, Apply and Commercialize Medical Devices & Technologies:

 * Internationally recognized lymphologist:
 * Part of an international network of researchers in lymphological disorders
 * Director and team leader of a multi-disciplinary team of researchers
 * Consultant and adviser to government, professional and industry groups
 * Published and presented over 300 articles including in Lymphology, New England Journal of Medicine, Australian Doctor, Medicine Today.
 * Regular presenter and invited speaker at international meetings, the most recent being the International Society of Lymphology meeting in Germany, the British Lymphology Society meeting in Glasgow, Vein meeting in Auckland and Phlebology meeting in Sydney.
 * Editor/Reviewer of international journals including, Lymphatic Research and Biology, US-China journal of Oncology and Lymphology, medical science monitor
 * Involved in screening programs for early detection of soft tissue changes in chronic disorders such as lymphoedema, oedemas and lipoedemas
 * Interested in the early detection and treatment of superficial tissue diseases and disorders
 * Developed techniques for the measurement of fibre and other changes in superficial tissues
 * Very strong commitment to patient and practitioner awareness raising and education
 * Runs a range of course for patients and health professionals in the areas of oedemas/lymphoedemas and their recognition
 * Recipient of over $1.6 million in Industry, Government and other grants in recent years.

- Extracted from Flinders University Medical Center website.

Flinders trial.
15th June 2000
Gordon Pan, head of Hsin Ten and Louise Hicks, Chairperson of Flinders University
Consulting, signing the contract for the clinical trial research project at Flinders University.

Piller chi machine cinical trials.

May 30th 2002 - Letter from Professor Neil Piller regarding the significance of the
clinical trial results using the Hsin Ten Sun Ancon Chi Machine (Aerobic Exerciser).

1) "Between 2000 and 2002 a large scale Clinical Trial was conducted at Flinders Medical Center on two groups of patients, one with chronic leg Secondary Lymphoedema and one with chronic leg Venous Oedema."

2) "It is obvious that the Sun Ancon Aerobic exerciser has a very significant impact on chronic limb swelling associated with failure of the lymphatic systems and compromised vascular systems combined with an overloaded lymphatic system even when used in the patient's home for 3 weeks. Given that some of the patients have had their problems for up to 30 years and that they were generally (to the time of the trial) receiving the best current treatments without great impact, these trial findings offer considerable hope for this group of patients."

Piller letter clinical trials.
Professor Neil Piller, Team Leader Lymphoedema Assessment Clinic,
Trial Leader of the Sun Ancon Chi Machine Clinical Trials.

3) "The trial results have been presented at the International Congress of lymphology meeting in Genoa in 2001 and are about to be published in the medical literature now the study is complete."

Flinders University Medical Research

The Sun Ancon Chi Machine clinical trials and the results.


Equipment trials come up trumps:

On Campus: March 28 - April 8, 2002: Researchers from the Department of Public Health Lymphoedema Assessment Clinic and Flinders Biomedical Engineering recently concluded trials on behalf of Hsin Ten Enterprises, a Taiwanese-based company.

Flinders team.

January 2002.
Amanda Moseley, Prof. Neil Piller, Louise Hicks, Dr. S. Birrell and Jerry Tsai (CEO of Hsin Ten).

The team of researchers was headed by Professor Neil Piller, a specialist in the treatment of oedemas, medical conditions that result in swelling of the legs through fluid retention. Loss of fluid and a reduction in the pain and swelling were among the results observed and evaluated over 21 days use of the machine by oedema sufferers. The research work was a feature of a recent ABC television program.

A recent function marked the conclusion of the project, and final results of the trial were presented by Flinders Consulting Chairman Ms Louise Hicks to Mr Jerry Tsai, President of Hsin Ten. In recognition of the researchers' efforts, Mr Tsai generously donated 20 of the company's Aerobic Exerciser machines to the Lymphoedema Assessment Clinic for further research and for selected use by suffers of oedemas. Hsin Ten representatives from both Taiwan and Sydney attended the function, and further collaborations with Flinders were now being discussed.

Dr Wayne Harvey, Managing Director of Flinders Consulting, said it was gratifying to see the increase in use and recognition of expertise offered by university researchers.

"The skills of university staff are increasingly being applied to commercial opportunities with community benefits," Dr Harvey said.
- Flinders University,


Available from HTE Australia

Flinders University has independently produced 3 booklets detailing the research findings and outlining the conditions of
1) Secondary Lymphoedema.
2) Venous Oedema.
3) Patient follow-up testimonials.

The booklets contain a condensed report of the findings of a large scale clinical trial contracted out to Professor Piller on behalf of Hsin Ten by Flinders Consulting, as well as providing instructions for the reader on how to take optimum care of their legs, with additional guidance regarding the types of treatments that may be available to them.

Flinders University has also produced an interactive DVD for educating professionals and patients about the lymphatic system and the clinical trial results. It features the Sun Ancon Chi Machine as an option of treatment. "The Vital Essence: Understanding the lymphatic system in health and disease" DVD is only available from Flinders University.  


Published medical articles regarding the Chi Machine clinical trial results:

Flinders University published their clinical trial results in the
1) Australian and New Zealand, Phlebology, November 2003 as did 2a) Lymphology, June 2004 and 2b) Lymphology, December 2002.


1) The Impact of the Sun Ancon Chi Machine Aerobic Exercise on Chronic Oedema of the Legs.  - by Mosley, Piller, Carati, Esterman - Medical Journal of Phlebology, November 2003.


2a) The Sun Ancon Chi Machine Aerobic Exerciser: a new patient focused, home-based therapy for people with chronic secondary leg lymphoedema. 

'A significant proportion of those who survive lower torso cancer treatments will go on to develop clinically discernible bilateral or unilateral leg lymphedema. Although beneficial treatments exist for this condition, many are expensive and involve visits to outpatient clinics or allied health professionals--making the patient dependent upon others for treatment and maintenance.

This clinical trial tested the efficacy of the Sun Ancon Chi Machine Aerobic Exerciser, a home based therapy that delivered both elevation and passive exercise to the legs. This machine was used in the participant's home according to a set regime with measurements being taken immediately before trial commencement, at weekly intervals and then 1 month after treatment cessation.

 After a three week treatment period there were statistically significant reductions in total leg volume and fluids, whole body extracellular fluid, weight and subjective leg symptoms. Lymphscintigraphy in a sub-group of patients suggested an increase in lymphatic transport in some individuals. Although some of the fluid and symptoms had returned at the 1 month follow up, none of the parameters had returned to pre-treatment levels.

This finding indicates that this equipment may have ongoing beneficial effects. This clinical trial demonstrates that the Sun Ancon Chi Machine Aerobic Exerciser is an effective adjunct therapy that can be used in the patient's own home.'

Department of Surgery and Lymphoedema Assessment Clinic, School of Medicine, Bedford Park, South Australia, Australia.
Lymphology. Issue 37, June 2004, p.43-4 - Moseley AL, Piller N, Esterman A, Carati C.

Sun Ancon Chi Machine SDM-888
Original Sun Ancon Chi Machine

2b) Combined opto-electronic perometry and bioimpedance to measure objectively the effectiveness of a new treatment intervention for chronic secondary leg lymphedema.

'Secondary lymphedema of the legs is a common sequela of patients treated for cancer of the reproductive, gastrointestinal, urinary systems and melanoma. From a clinical and research perspective it is of utmost importance to use techniques that objectively quantify leg volume and fluid composition as an indicator of lymphedema severity and response to treatment.

Two techniques often used in both the clinical and research setting are leg perometry and multi-frequency bioimpedance. Although both techniques have been extensively validated, this trial aimed to cross correlate both measurement techniques to ascertain whether each or both could be used reliably for measurement of leg lymphedema.

These measurements were utilized throughout a clinical trial that assessed the effectiveness of a new home based treatment program in the form of the Sun Ancon Aerobic Exerciser. This machine delivered both elevation and passive exercise to the legs, with participants using the machine over a three week period during which time their leg volumes were measured using both perometry and bioimpedance.

The results demonstrated that leg volume measurements decreased using both perometry and bioimpedance. The reduction in body extracellular fluid as measured by bioimpedance correlated well with a reduction in leg volume as measured by perometry. Bioimpedance also recorded a reduction in weight, which was correlated with the reduction in leg volume as measured by perometry.

This trial confirms that perometry and bioimpedance were both effective in independently showing a reduction in leg lymphedema using the Aerobic Exerciser therapy, and that both methods can be reliably used to measure and follow leg lymphedema.'

Lymphedema Assessment Clinic, Flinders Surgical Oncology Unit, Department of Public Health School of Medicine, Flinders Medical Centre, Bedford Park, Adelaide, South Australia.
Lymphology. Issue 35, December 2002, p.136-43 - Moseley A, Piller N, Carati C.

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